Ana-Maria Totea

Dr Ana-Maria Totea PhD

Lecturer in Pharmaceutical Science

Ana joined the University of Greenwich in 2023 as a Lecturer in Pharmaceutical Science. She previously worked as a Postdoctoral Researcher at the University of Huddersfield on a project in collaboration with Paxman Scalp Cooling. The role involved the formulation of a topically applied product aimed to enhance the effect of scalp cooling and change the lives of millions of people undergoing chemotherapy.

Ana worked in industry as a development scientist between 2019 and 2021 for Thornton & Ross, in the development and validation of analytical methods such as high-performance liquid chromatography following the ICH and GMP guidelines. She holds a PhD in Pharmaceutical Sciences from the University of Huddersfield, and a BSc in Pharmaceutical Sciences from the University of Greenwich.

Pharmaceutical science

Responsibilities within the university

Module contribution

  • Colloids and Structured Materials
  • Modern Pharmaceutical Processing and Active Ingredient Delivery
  • Pharmaceutics
  • Practical and Professional Skills Chemistry

Recognition

Member of the Royal Society of Chemistry

Member of the Academy of Pharmaceutical Sciences

Key projects

The Royal Society of Chemistry Outreach Fund. Project name: My best friend, the Earth!  £5000. October 2023 - November 2024.

Recent publications

Totea, A. M., Dorin, I., Laity, P. R., Conway, B. R., Waters, L., & Asare-Addo, K. (2021). Magnesium Aluminium Silicate-Metformin Hydrochloride Complexes-The Use of Isothermal Calorimetry for Probing Clay and Drug Nanocomplexations. Current Drug Delivery, 18(9), 1280-1291. https://doi.org/10.2174/1567201818666210402125244

Totea, A. M., Dorin, I., Laity, P. R., Sabin, J., Conway, B. R., Waters, L., & Asare-Addo, K. (2020). A molecular understanding of magnesium aluminium silicate–drug, drug–polymer, magnesium aluminium silicate–polymer nanocomposite complex interactions in modulating drug release: Towards zero order release. European Journal of Pharmaceutics and Biopharmaceutics, 154, 270-282. https://doi.org/10.1016/j.ejpb.2020.07.027

Totea, A. M., Dorin, I., Laity, P. R., Conway, B. R., Waters, L., & Asare-Addo, K. (2020). Use of thermodynamics in understanding drug release from xanthan gum matrices: The influence of clay-drug complexes. Carbohydrate Polymer Technologies and Applications, 1, 100012.  https://doi.org/10.1016/j.carpta.2020.100012

Totea, A. (2020). Characterisation of smectite clay-drug complexes in polymer matrices using isothermal titration calorimetry and evaluation of drug release

Totea, A., Sabin, J., Dorin, I., Hemming, K., Laity, P. R., Conway, B. R., Waters, L., & Asare-Addo, K. (2020;2019;). Thermodynamics of clay–drug complex dispersions: Isothermal titration calorimetry and high-performance liquid chromatography. Journal of Pharmaceutical Analysis, 10(1), 78-85. https://doi.org/10.1016/j.jpha.2019.12.001

Asare-Addo, K., Totea, A., & Nokhodchi, A. (2020). Drug release from magnesium aluminium silicate-polyethylene oxide (PEO) nanocomposite matrices: An investigation using the USP III apparatus. European Journal of Pharmaceutical Sciences, 153, 105474-105474. https://doi.org/10.1016/j.ejps.2020.105474

Asare-Addo, K., Walton, K., Ward, A., Totea, A., Taheri, S., Alshafiee, M., Mawla, N., Bondi, A., Evans, W., Adebisi, A., Conway, B. R., & Timmins, P. (2018). Direct imaging of the dissolution of salt forms of a carboxylic acid drug. International Journal of Pharmaceutics, 551(1-2), 290-299. https://doi.org/10.1016/j.ijpharm.2018.09.048

Asare-Addo, K., Alshafiee, M., Walton, K., Ward, A., Totea, A., Taheri, S., Mawla, N., Adebisi, A. O., Elawad, S., Diza, C., Timmins, P., & Conway, B. R. (2019). Effect of preparation method on the surface properties and UV imaging of indomethacin solid dispersions. European Journal of Pharmaceutics and Biopharmaceutics, 137, 148-163. https://doi.org/10.1016/j.ejpb.2019.03.002

Totea, A., Sabin, J., Dorin, I., Hemming, K., Laity, P. R., Conway, B. R., Waters, L., & Asare-Addo, K. (2020). Thermodynamics of clay drug complex dispersions: Isothermal titration calorimetry and high-performance liquid chromatography. Journal of Pharmaceutical Analysis, 10(1), 78-85. https://doi.org/10.1016/j.jpha.2019.12.001

J.S. Boateng, A.M. Popescu. Composite bi-layered erodible films for potential ocular drug delivery. Colloids and Surfaces B: Biointerfaces 2016; 145: 353.  https://doi.org/10.1016/j.colsurfb.2016.05.014

Presentations

Use of Nanostructured Lipid Carriers as Platform for Delivery of Antioxidants to the Skin and Hair Follicles to Enhance the Effects of Scalp Cooling in a Bid to Change the Face of Cancer – APS PharmSci Conference, Reading, 6 Sep 2023