The mass spectrometry facility has hosted two awardees of the BMSS medal for lifetime contribution to mass spectrometry (Professor Tony Mallet and Professor Frank Pullen) and cutting edge instrumentation including direct analysis in real-time ionisation, measurement of accurate mass and a Waters Synapt G2 ESI-qTOF incorporating ion mobility.
Mass spectrometry is a powerful analytical tool with many diverse applications. We enable access to state-of-the-art instrumentation, along with the necessary expertise to develop your research in many areas such as drug characterisation, gas-phase ion chemistry, proteomics, environmental analysis and many more.
We actively encourage users and collaborators from academic institutions and commercial enterprises.
Services
Our breadth of instrumentation and expertise allows us to offer a range of services at competitive rates:
We provide:
- Service work (customer focused and confidential)
- Hourly instrument use, including support and training
- Long term contracts
- Training
- Consultancy, including working side-by-side with our experts.
In addition to mass spectrometry instrumentation and expertise we also have experience of a wide array of interpretation software to understand fragmentation, sequencing, deconvolution, principal component analysis, quantification etc. and access to various chemical databases to aid interpretation.
Examples of recent projects:
- High resolution, high mass accuracy measurements and structure determination
- Metabolite analysis in urine
- Structure elucidation in natural products
- Pesticide analysis from complex biological matrices
- Forensic analysis.
We work with our colleagues at the University of Greenwich and collaborators to provide solutions to analytical challenges.
Our experts
Frank Pullen
Professor of Pharmaceutical Analysis, PhD, CSci, CChem, FRSC
Professor Frank Pullen has 30 years experience in organic mass spectrometry within the pharmaceutical industry, in-depth knowledge in drug discovery and development and published widely in peer reviewed journals. He is on the editorial board for the journal, Rapid Communications in Mass Spectrometry, and is also a member of the EPSRC grant review college.
Professor Pullen was formerly the holder of the British Mass Spectrometry Lectureship; a position that is bestowed for a one year duration. He is also a member of the advisory board to the British Mass Spectrometry Society; chairman of the Scientific Advisory Board for the University of York's Centre of Excellence for Mass Spectrometry and the company Microsaic; and sits on the editorial board of the journal Rapid Communications in Mass Spectrometry.
Dr Charles A. I. Goodall
Head of Mass Spectrometry Services
Charles studied Theoretical Physics at the University of York, Chemistry at the University of Nottingham, then completed his Doctorate in Radical-propagated Photochemistry under Professor P S Monks at the University of Leicester. During his doctoral research Charles participated in 9 international field campaigns in collaboration with the University of Manchester, the University of York, NCAS, CIRES (Boulder, Colorado) and the University of Wisconsin-Madison, ranging from studying the contribution of marine algae to remote-oceanic cloud formation, to the impact of Megacities on local and regional climate. Following completion of his doctorate Charles then worked at the Real-time Air Fingerprinting Technologies laboratory at the University of Leicester, developing spectroscopic and mass spectrometric platforms for monitoring NMHC emissions from motor vehicles.
Over the last 15 years Charles has also worked within the Biosciences, Consumer Nutrition and Environmental Compliance sectors, and is a member of the Erasmus+ Programme providing specialist mass spectrometry support assisting Serbian and Albanian HEI and NGO bodies within the Food and Environmental Safety sectors.
Publications
- Ashrafi, Nadia, Lapthorn, Cristian, Pullen, Francis, Naclerio, Fernando and Nielsen, Birthe V. (2017) High performance liquid chromatography coupled to electrospray ionisation mass spectrometry method for the detection of salivary human neutrophil alpha defensins HNP1, HNP2, HNP3 and HNP4. Analytical Methods, 46 (9). pp. 6482-6490.
- Lapthorn, Cris, Pullen, Frank S., Chowdhry, Babur Z., Wright, Patricia, Perkins, George L. and Heredia, Yanira (2015) How useful is molecular modelling in combination with ion mobility mass spectrometry for 'small molecule' ion mobility collision cross-sections? Analyst, 140 (20). pp. 6814-6823.
- Lapthorn, Cris, Pullen, Frank, Chowdhry, Babur, Perkins, George, Dines, Trevor and McCullagh, Michael (2014) The effect of charge location in ion mobility mass spectrometry for small molecule analytes. In: 62nd ASMS Conference on Mass Spectrometry and Allied Topics, 15-19 Jun 2014, Baltimore, MD, USA.
- Lapthorn, Cris, Dines, Trevor J., Chowdhry, Babur Z., Perkins, George L. and Pullen, Frank S. (2013) Can ion mobility mass spectrometry and density functional theory help elucidate protonation sites in 'small' molecules? Rapid Communications in Mass Spectrometry, 27 (21). pp. 2399-2410.
- Lapthorn, Cris, Pullen, Frank and Chowdhry, Babur Z. (2013) Ion mobility spectrometry-mass spectrometry (IMS-MS) of small molecules: separating and assigning structures to ions. Mass Spectrometry Reviews, 32 (1). pp. 43-71.
Contact
Please contact us to discuss how we can help to advance your research through the application of mass spectrometry.
Professor Dave Wray, Mass Spectrometry Services,
Faculty of Engineering & Science,
University of Greenwich,
Medway Campus,
Central Avenue,
Chatham Maritime,
Kent, ME4 4TB
Tel: 020 8331 9800
Email: d.wray@greenwich.ac.uk